Assignment Instructions

What formulation strategy would you employ to bypass the absorption of the drug in the stomach.Discuss.

Description

Assignment – 1 Based on Pharmaceutical Pre-formulation and Unit processing (~1000 words)

Assignment 1 – Total marks – 25 (~ 1000 words) Part A – What is preformulation and why is it important ? (10 marks)

Part B – Write an account (with appropriate examples) on how each of the following excipient’s may influence drug absorption from the Gastrointestinal (GI)Tract.

a. Surfactants [3 marks]

b. Lubricants and Glidants [3 marks]

c. Binders [3 marks]

d. Disintegrants [3 marks]

e. Viscosity enhancers / suspending agents. [3 marks]

 

Assignment 2: Answer all questions. (marks 25) [> 1000 words]

A. Draw a schematic showing the steps involved in the manufacture of tablets?

[2 marks]

B. Describe in detail any seven of the steps listed in part (A), including the equipment required for such a process to occur, any equations used in the development of such a process and the mechanism of action if applicable. [14 marks]

C. What formulation strategy would you employ to bypass the absorption of the drug in the stomach. [ 2 marks]

D. Following tablet compression, 10 tablets were dusted and found to weigh 8.98 g. After removal from the friability tester they were dusted and re-weighed and collectively found to weigh 7.86 g. Discuss the significance of these results and suggest an appropriate method to improve them. [3 marks]

E. Preliminary tests on the blend found the tapped density was 8 and bulk density was 4, Calculate Carr’s compressibility index. Discuss the significance of these results and suggest an appropriate strategy to overcome any problems associated with this new powder blend [4 marks]

The post What formulation strategy would you employ to bypass the absorption of the drug in the stomach.Discuss appeared first on Bestchoice Writers.

What formulation strategy would you employ to bypass the absorption of the drug in the stomach.Discuss

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